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The Brain of Confusion is an Expert Mode accessory item from the Treasure Bag dropped by the Brain of Cthulhu. When you take damage while having this item equipped, some nearby enemies will become confused for 3-5 seconds (longer if the player received more damage, shorter if they are further away). The chance of them becoming confused (assuming they are not immune) is 60%, +0.4% per point of damage.
- The effect can be activated by any form of damage including damage taken by traps and thorn bushes.
- Many people consider the Brain of Confusion to be a major disappointment, as opposed to its Corruption counterpart, the Worm Scarf, which reduces damage taken by 17%.