Guide:Skeletron Prime strategies
Skeletron Prime, the Hardmode version of Skeletron, is intended to be the most difficult Hardmode boss, at least before 1.2. His high health, defense, damage, and multiple limbs will take a lot of punishment, and his limbs have the added effect of blocking non-piercing shots aimed at his head.
 Terrain preparation
An ideal arena for Skeletron Prime should consist of several rows of wood platforms. A full stack of 99 for each row should provide ample running distance to avoid his attacks, though it never hurts to have a longer arena. The platforms should be suspended off the ground, to prevent the Prime Cannon's grenades from ever detonating. A solid ceiling should be avoided, since Skeletron Prime will often retreat a fair distance when not using his spinning attack.
Another strategy is to create a bridge of Meteorite or preferably Hellstone, so you receive low damage from those blocks, rather than the high damage from Skeletron Prime. In this case you should stay on the Meteorite/Hellstone, rather than more around and evade attacks. (extremely dangerous in update 1.2)
As with most bosses, starting the battle as soon as the sun sets will provide the maximum amount of time to beat Skeletron Prime, which is vital since defeating him can take all night.
 Useful bug
Summoning Skeletron Prime from high altitude (at least Floating Island altitude), then teleporting far enough below, can cause 1,2,3 or all of his limbs to disappear. You then only need to worry about the head and possibly one or two limbs, making the battle relatively easy.
- Create a spawn point at your arena by crafting and placing a Bed there, then right-clicking it.
- Build a small Sky Bridge directly above the spawn location, but much higher -- preferably near the extreme top of the map. If you have Wings and the Ice Rod, you can do this easily by flying to the top of the map and summoning an ice block just below the edge of the map, then place ordinary blocks next to it. Land on this new platform.
- Summon Skeletron Prime with the Mechanical Skull and immediately use the Magic Mirror.
- You may see some of Skeletron Prime's projectiles fly at you briefly, but when he arrives at your location, most of his limbs should be gone.
Tip: This affect can also be achieved with a long skybridge made out of asphalt and utilizing a form of speed boots. One or two of the slower limbs will despawn, leaving the head and the other two or three limbs.(verified)
 Gearing up
Adamantite or titanium armor should be used if the player has not collected the bars necessary for Hallowed armor. Both the ranged and melee bonus helmets are helpful to keep on hand, as the melee bonus can be used to resist Skeletron Prime's initial attacks until his melee capacity is reduced, at which point the ranged bonus will provide extra damage without the defense loss being too much of a concern.
Since 1.2, killing Hardmode bosses gives you Hallowed Bars. You will need Hallowed bars to create Hallowed armor. You can farm an easy Hardmode Boss, such as The Destroyer, which is generally considered the easiest, and use the bars to make a full set of Hallowed armor. It may take 2-3 kills of the chosen Hardmode Boss, but the grinding is worth it. Another use of the bars is to make a Drax or Pickaxe Axe so you can mine chlorophyte and make Turtle armor for even more defense.
The Adamantite Repeater with Cursed Arrows is the optimal weapon for players who have yet to beat any hardmode boss. The Hallowed Repeater or Chlorophyte Shotbow and Megashark with Crystal Bullets or Cursed Bullets present a better alternative if either The Twins or The Destroyer have been defeated. Other weapons that work quite well are the Clockwork Assault Rifle (With Cursed or Crystal Bullets) because it has reasonable damage and a good range and Star Cannon and Flamethrower, for their ability to damage multiple parts.
If you have gotten a Arms Dealer and a Demolitionist, you can buy some explosive powder and some empty bullets to make Explosive Bullets. Each empty bullet is 3 copper, and each explosive powder is 17 silver. Money shouldn't be much of a concern here, so craft as many as needed. The explosion radius of the bullets may damage 2 segments of Skeletron Prime's limbs, making it twice as easy to remove the limbs.
An excellent strategy for those having trouble fighting Skeletron Prime is to acquire the Scourge of the Corruptor. This weapon will make short work of him provided you have the armor and/or potions to stay alive through the fight. It uses no mana, no ammunition, and after some time can amass a frightening swarm of tiny eaters which, if they ever manage to catch up to any part of him, will inflict an unreal amount of damage.
Overall the best weapon is the Vampire Knives if the player has it, with good armor the player won't lose much health. It is possible to kill Skeletron Prime five or more times on a single night without the use of any potion.
Accessories that improve mobility are a must, particularly the Spectre Boots. Angel Wings or Demon Wings will further aid in avoiding his attacks and preventing fall damage. The Obsidian Shield will prevent knockback. The final accessory should help in preventing direct damage; the Philosopher's Stone, Band of Regeneration, or Cross Necklace are all good choices. In case you choose to take damage from the Meteorite/Hellstone bridge the movement accessories should be replaced by more accessories to prevent direct damage, including the Cross Necklace and possibly the Star Cloak. Furthermore you should use an Cobalt Shield instead of an Obsidian Shield. All accessories should be reforged for damage or defense bonuses, at least +2 for each.
If you go through the trouble of killing a Paladin in the Hardmode Dungeon, you can get a Paladin's Shield. This accessory give you 6 defense when equipped, and if it is reforged to Warding, you can get a 10 defense bonus! This is worth it, as Skeletron Prime's damage can now be reduced even further than 53. Just be careful, as the Paladin has 5000 health, and does more damage than Skeletron Prime!
Bring plenty of Greater Healing Potions, at least ten to be on the safe side. The Regeneration Potion and the Ironskin Potion will help prevent fatal damage, but will often wear out before the battle is over. Two of each will cover the entire night. A Bowl of Soup will provide a further advantage. Also the Gravitation Potion may be useful if you want to free up another accessory slot, although you may want to keep a pair of wings or a Lucky Horseshoe equipped to prevent falling damage. The last type of potions that are very useful are swiftness potions, because they help you evading his limbs, especially if you decide to use a Gravitation Potion instead of Spectre Boots.
If you are wearing full turtle armor when daytime arrives, skeletron prime will charge at you and (like a Dungeon Guardian) instantly kill you and fly away. However, in the result of dealing 10000 damage to you, the armor will also deal the same damage to Skeletron Prime, effectively instant-killing him. The game will still handle this as your kill and he will drop all of his loot as normal.
 The battle
Skeletron Prime is a flying boss that consists of five parts:
- Prime Saw, a melee arm, with 8000 health.
- Prime Vice, a melee arm, with 8000 health.
- Prime Laser, a ranged arm that fires lasers, with 5000 health.
- Prime Cannon, a ranged arm that fires grenades, with 6000 health.
- Skeletron Prime, the head, with 25000 health.
Each piece has a specific method of attack, but only killing the head will defeat the boss, meaning the other parts can potentially be ignored. Due their habit of blocking attacks, however, at least one or two should be destroyed to make beating Skeletron Prime easier.
Tip: Never try to tank this boss. He is no 2800-health-30-damage pushover!
 Prime Saw
Prime Saw is Skeletron Prime's most prominent melee attack limb, and the one that will do the most damage of any limb. At regular intervals, it will chase down the player, causing serious collision damage each time it hits. The arm can move as fast as the player can with Spectre Boots, and will accelerate in short bursts so it can catch up. It will eventually pull back to the head, waiting to repeat the cycle.
As it does a lot of damage, this arm should be destroyed first. By using the wooden platforms to change height when it charges, or with great speed, Prime Saw's attacks can be avoided until it is destroyed. Using the melee set bonus will help mitigate damage taken, after which the ranged set can be equipped.
 Prime Vice
Prime Vice is Skeletron Prime's secondary melee arm. Though it will occasionally chase the player, it is more common for the arm to simply charge directly at the player, retract, then attack again. This arm is relatively easy to dodge, making it a minimal threat to an agile player.
 Prime Laser
Prime Laser will consistently remain above the player, firing one laser every second or so. The lasers aren't as damaging as melee attacks and can be avoided fairly easily, but are harder to dodge if attempting to damage the head. Its low defense and health make destroying it much easier than the other limbs, so it may be worth removing simply to make the head easier to target.
 Prime Cannon
Prime Cannon fires grenades at a rate faster than Prime Laser, which also do more damage. However, these grenades only detonate on contact with a solid block. In a wood platform arena, this effectively renders Prime Cannon a nuisance that occasionally blocks attacks. Leaving it intact buys more time to defeat the head.
 Skeletron Prime
Skeletron Prime is the head, which must be destroyed to win. Skeletron Prime will try to float above the player at all times (use this opportunity by shooting the head from below), high enough that he may be entirely off-screen at lower resolutions. He'll close in to do his spinning attack, which doubles his attack and defense. Once he finishes spinning, he'll retreat again. If the head is not destroyed by morning, it will be locked in its spinning attack, gain a speed increase, and its attack and defense will increase to near-unbeatable levels. In this state, a single hit will kill the player, while the head will only take one or two damage per hit.
When trying to destroy the head, it helps to have destroyed at least two of its limbs first. The remaining two usually won't block too many of your shots. Using the ranged set bonus is recommended, since the extra damage and ammo conservation will make destroying it easier. His attacks are relatively simple to dodge, and though he can cause a lot of damage, getting hit once or twice isn't a very big deal since he doesn't attack too frequently. The wings and Spectre Boots make it almost impossible for it to hit you.
When Skeletron Prime stops attacking and tries to retreat, chase it down using the wings. Though they'll eventually give out, you'll do a fair amount of damage on the way up. The head will come back down fairly quickly. Attack the head constantly and it should be destroyed before morning.
As a last resort strategy, if you are equipping the turtle armor, just before morning, start bashing into Skeletron Prime's head. Since the damage dealt by Skeletron Prime in his insta-kill phase is massive, you can kill him in a suicide attack. Since its drops does not disappear after you die, you can locate and claim your drops easily. However, it is wise to have reduced Prime's health to lower than 15000 before morning. In multiplayer, this can be used to farm souls and hallowed bar, summoning the Prime just before dawn, 1 or 2 players using turtle armor, while the others distract Prime until the turtles re spawn. However, be sure to crash into his head BEFORE morning comes, because or else you could be picked off in the way by other arms, particularly the laser.
Caution: Even with the best armor and defense possible, Skeletron Prime can still easily kill you, as the head's damage while spinning can only be reduced to 53.
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