Dr. Man Fly is a Hardmode, post-Plantera enemy from the Solar Eclipse event. It mainly attacks by throwing Toxic Flasks at the player, dealing area damage. It gives the player a warning about an oncoming Toxic Flask attack by pausing in place. Like the Nailhead and Eyezor, they appear to traverse much slower than many of the other Solar Eclipse enemies, leaving the player enough time to plan a safe attack against them.
- Dr. Man Fly is a reference to the 1958 film The Fly.
- The Bestiary entry for the Dr. Man Fly: "Part man, part fly, all doctor. He's brought his most volatile and dangerous chemicals, and he's buzzing to try them out."