Guide:Brain of Cthulhu strategies

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This is a Guide page. This means the page will walk you through a specific task, strategy, or enemy/boss fight.

This guide is about Brain of Cthulhu, which is exclusive to Crimson worlds. Player playing in Corruption worlds should check Guide:Eater of Worlds strategies instead.

"A horrible chill goes down your spine..."

The Brain of Cthulhu is Pre-Hardmode boss. It's The Crimson counterpart of Eater of Worlds.

Brain of CthulhuFirst Form

Statistics

Type	Boss
Environment	The Crimson
AI Type	Brain of Cthulhu AI
Damage	30 / 54
Max Life	1000 / 1700 3000-4000 / 5700-7700 (with creepers)
Defense	14
KB Resist	100%
Inflicts debuff	Slow 12.5% chance
Debuff duration	8.75 - 17.5 seconds
Debuff tooltip	Movement speed is reduced
Immune to

Drops

Coins	5

Map Icon

• Internal NPC ID: 266

Brain of CthulhuSecond Form

Statistics

Type	Boss
Environment	The Crimson
AI Type	Brain of Cthulhu AI
Damage	30 / 54
Max Life	1000 / 1700
Defense	14
KB Resist	100%
Inflicts debuff	Slow 12.5% chance
Debuff duration	8.75 - 17.5 seconds
Debuff tooltip	Movement speed is reduced
Immune to

Drops

Coins	5

• Item (Quantity)Rate
• Brain of Cthulhu Mask
  14.29%
• Brain of Cthulhu Trophy
  10%
• Crimtane Ore (40-90)
  100%
• Lesser Healing Potion (5-15)
  100%
• Tissue Sample (30-50)
  100%
• Bone Rattle 
  5%
• Treasure Bag (Brain of Cthulhu)

  • Brain of Confusion 

  100%

Map Icon

• Internal NPC ID: 266

Spawn Conditions

The Brain of Cthulhu can be spawned by fulfilling one of these conditions:

• Smash three Crimson Hearts.
• Use Bloody Spine.

It must then be defeated within the Crimson: getting out of it will make it retreat and despawn.

The Fight

Brain of Cthulhu has 2 phases, with the latter starting after all Creepers have been dealt with.

First Phase

The Brain cannot be attacked in this phase, only the Creepers can. The Brain will teleport to a spot in the arena, then slowly advance towards you. The Creepers will follow shortly after, and will clump up with the brain for a few seconds, before the Brain teleports again and the Creepers will follow. The idea is that the Brain will teleport behind you, which will make the Creepers to fly into you, causing damage. Jump out of the way, either by using your platforms or with an extra jump, then attack the Creepers. Use piercing weapons to speed up the process. When a Creeper dies it can drop either Crimtane Ore or Tissue Sample.

Second Phase

When all of the Creepers are dead, the Brain will split, revealing a Heart with an Eye on the inside. The Brain teleports much more frequently, often at unexpected angles, and will try to ram into you. He only has 1000 health, so he can be killed fairly quickly. Keep using your platforms to jump out of the way. Use your strongest weapon to take down the Brain. If you have a weapon with high knockback, it will excel at dealing with the Brain, so much so that it's possible to stand in one location and attack it whenever it gets close.

Expert Mode

The Creepers are much more aggressive. They will actively try to fly into you, even ignoring the Brain if it means an opportunity to land an extra hit or two. They can also inflict a large variety of debuffs:

• Confused: reverses the movement buttons;
• Poisoned: saps 2 health per second;
• Bleeding: stops health renegeration;
• Darkness: reduces vision;
• Silenced: makes you unable to cast any Magic weapons;
• Broken Armor: reduces your Defense by half;
• Weak: reduces Melee damage and Attack speed, Movement speed and Defense by 4.

During the Second Phase, the Brain will spawn clones of itself around the player. They serve as decoys, and while they cannot be attacked they can confuse the player. They start off as barely visible but as the Brain loses more health the clones will become more opaque. At low health the clones will be completely visible. The Brain will also become faster as it loses health. Life-draining debuffs such as On Fire and Frostburn, or a Hunter Potion will help distinguish them. Additionally, summoned Minions will always target the correct copy.

General Strategies

General Tips

This content is transcluded from Guide:Practical Tips#Combat.

• Starting the battle as soon as the sun sets (at 7:30 p.m.) will provide the maximum amount of time to defeat nocturnal bosses.
• Prepare your Boss-fighting arena with adequate lighting, Campfires and Heart Lanterns for health regeneration, and Stars in Bottles for mana regeneration if you use magic.
•   Sunflowers provide the Happy! buff to players within a 50-tile radius, which grants a +10% movement speed bonus and 17% reduction in enemy spawn rate.
• Always carry at least one stack of the highest-tier healing potion available (Lesser, Normal, Greater, or Super Healing Potions ). Relying only on natural Health Regeneration is not a good idea.
  • The same goes for Lesser, Normal, Greater, or Super Mana Potions   , if you use Magic.

• Bosses are displayed on the Minimap: Follow the boss's icon to track it when you're struggling to find it. You can identify the boss icons by checking their respective wiki pages.
• Once you have freed the Mechanic in the Dungeon, you can use Wire to enhance your arena with Traps and helpful Heart and Star Statues. The former help to damage the enemies, though be careful to set them up correctly in order not to hurt yourself during the battle. The latter will spawn heart and star pickups, respectively. Connect these devices to timers.
• It may be useful to summon and kill the Eye of Cthulhu before summoning any harder boss in order to spawn an extra one-use pool of hearts.
• Remember to use the Sharpening Station , Ammo Box   , Crystal Ball, and Bewitching Table  before you go to explore or battle Bosses / Invasions. These will give class-specific boosts that are useful to take. They respectively give Sharpened , Ammo Box   , Clairvoyance, and Bewitched .

Terrain Preparation

Standard 5 layer arena.

Your arena will have to be built in The Crimson, because it can only be summoned there. Since the Brain of Cthulhu spawns as soon as you smash a third Crimson Heart, you're likely to be in a very enclosed area when the fight begins. This can lead to you to being swarmed by the Creepers and get overwhelmed. This can be avoided by preparing the chasm's main chamber as an arena beforehand, and choosing which Hearts to break first:

• For the first two, pick the least convenient hearts (distant, above the main chamber, underwater, etc).
• For the third, pick the closest to the main chamber, toss a Bomb or another explosive and quickly go to your arena while it falls.

If summoned with a Bloody Spine, then the arena can simply be made in the Surface, however do not make it very tall, as jumping too far above it will be considered exiting the Crimson, causing the Brain of Cthulhu to despawn.

Gearing up

It is recommended to have at least 200 Life and 100 Mana, which requires 5 Life and Mana Crystals: if you've done some spelunking you're bound to have come across this many.

You're going to need at least Iron or Lead armor. Gold armor or Platinum armor is a great defensive choice with high defensive values for this point in the game.

For those playing during Halloween (or have planted some Pumpkin Seeds), you can harvest Pumpkins for Pumpkin armor which has the same defense value as Iron's, but it trades off the +2 defense bonus with a helpful 10% damage bonus.

Weapons

For Melee users:

• Any large sword, such as the Blood Butcherer will prove effective against the Creepers. The Falcon Blade is useful for the Brain of Cthulhu's second phase, as its rapid speed, somewhat high damage, and decent knockback will keep it at bay. The Katana, sold from the Travelling Merchant, is a fast sword with decent knockback and a high critical rate.
• A Spear is a great weapon against the Brain of Cthulhu, especially during the second stage. Suggested options are the Trident and The Rotted Fork.
• A Flail of some kind is beneficial for taking out the Creepers; the easiest to obtain would be the Ball O' Hurt, but this will require you to make another world with The Corruption in it, as it cannot be acquired in a Crimson world. You could instead try to obtain the Chain Knife, rarely dropped by Cave Bats, but unlike the previously mentioned flail, it cannot pierce.

For Ranged users:

• Tendon Bow is the most powerful bow at this stage. You can combine it with Jester's Arrows, which greatly help to kill the swarm of Creepers. However, you can also use the Flaming Arrows as a cheaper alternative; the On Fire! debuff will be helpful during the second stage.
• As The Undertaker can be obtained very easily (as it's a guaranteed first-time loot from the Hearts), it's a good weapon to use against the Brain. The Musket Balls that spawn with it should be sufficient, but you can craft (or buy) Silver Bullets, which deal slightly more damage.

For Magic users:

• The Water Bolt and Crimson Rod are good choices, and are obtained fairly easily. They greatly benefit from fighting in an enclosed area.
• The Diamond Staff is easy to make, but it's time-consuming. But you'll find its piercing ability excel at dealing with the Creepers.
• If you're willing to make a quick detour to a Corruption world, the Vilethorn works fantastically against the Creepers and is a great weapon in general.
• If you already farmed a Meteorite, you can use the excellent Space Gun: it's piercing ability will clear out the Creepers fairly easily.

For Throwing users:

• Shurikens and Throwing Knifes, with their Penetration, can be helpful for killing Creepers. Poisoned Knifes can be crafted using Vicious Powder and Throwing Knives and deal a little extra damage.
• If you are willing to risk, Grenades are great choices for dealing with the Creepers, but you have to watch out for the blast radius, as you will take damage from it.
• Molotov Cocktails   , while expensive to make (as Pinkies aren't common), is a superb weapon. The splash damage and the fire that hits multiple times can keep the Brain away in its second Stage.

For Summoners:

At this stage of the game, it's better to use any of the already mentioned Gear tips, as there isn't much to use, unless you want to kill Queen Bee first, which is not recommended at this time.

Potions

• The Ironskin Potion, the Swiftness Potion and the Regeneration Potion will do you well.
• You should try to get the Well Fed Buff in some way; you can get this from Cooked Fish or Pumpkin Pie.

Accessories

• The Cloud in a Bottle will give you a double-jump ability which will greatly help with evasion. Look out for the improved versions, such as the Tsunami in a Bottle, the Blizzard in a Bottle or the Sandstorm in a Bottle.
• The Hermes Boots will increase your speed and aid greatly in evasion. You can upgrade them to the Spectre Boots for the added bonus of a few seconds of flight, but this requires the Goblin Tinkerer, which the player may not have yet.
• The Band of Regeneration is a decent accessory which will slowly regenerate your life; it equates to one heart restored every 40 seconds. Not terribly useful but it's suggested if you have a slot you need to fill.
• The Anklet of the Wind gives a basic 10% speed boost, which will help out with evasion. You can replace it with the Aglet which is much easier to find but only offers a 5% speed boost.
• The Frog Leg will give you improved jumping abilities, including increased height and automatic jumping but it can only be found by fishing, with an incredibly rare 1:500 chance to get it.
• If one is playing in Expert mode, the Shield of Cthulhu is a great choice for quick evasion, and extra damage in the Brain's second phase.

Specific Strategies

Water Bolt box Method

If you can get a Water Bolt from the Dungeon, it allows for a fairly good advanced strategy: Build a closed box (about 15x15), making sure you can get into it quickly for the fight. Once the Brain appears, spam the Water Bolt to fill the box with bouncing bolts, which will rapidly kill Creepers passing through (quickly triggering the Brain's second form), then keep the Brain mostly away from you by knocking it back it every time it comes through the box. Make sure you have enough Mana or a Mana Flower!